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End-to-end analysis

heart()
HEART: end-to-end analysis from individual-level data

Step 1: estimation and decorrelation

heart_assoc()
Per-variant target-only, auxiliary and decorrelated estimators
heart_density_ratio()
Density ratio between the target and the pooled population
heart_meta()
Decorrelated inverse-variance meta-analysis from summary statistics

Step 2: adaptive transfer via null decomposition

heart_test()
HEART test: adaptive transfer via null decomposition
heart_pi_estimate()
Estimate the four-group proportions from a pair of p-value sequences
heart_tail_estimate()
Estimate the left-tail parameters of the alternative p-value density
heart_statistic()
HEART test statistic
heart_null_cdf()
Composite null distribution of the HEART statistic

Simulation

heart_simulate()
Simulate target / source data under the four-group model

Package

HEART HEART-package
HEART: Heterogeneity-aware Empowerment via Adaptive Robust Transfer